NAD Research
Nicotinamide Adenine Dinucleotide (NAD) is a molecule essential for cellular function and energy production. Research suggests NAD levels decline with age, potentially contributing to age-related health concerns.
Studies, particularly in animal models, have explored NAD's potential as a longevity supplement. Some research shows promise in boosting NAD levels using precursor molecules like nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN). These studies suggest potential benefits for metabolism, cellular repair, and even lifespan extension.
However, human trials are still ongoing, and the long-term effects and optimal dosages for NAD supplementation remain under investigation. At Charava, we closely monitor the latest research on NAD and its potential role in promoting healthy aging.
Below is a list of some of the interesting research and clinical trials on Nicotinamide Adenine Dinucleotide.
For more details, please refer to PubMed.
1. “Dietary Supplementation With NAD+-Boosting Compounds in Humans”
Published: April 2023
This study reviews the safety and efficacy of direct NAD+ supplementation in elevating NAD+ levels across various tissues.
2. “Nicotinamide Adenine Dinucleotide Metabolism and Arterial Stiffness”
Published: February 2023
Investigates the effects of long-term NAD+ supplementation on arterial stiffness in middle-aged adults.
3. “Nicotinamide Adenine Dinucleotide Concentration and Supplementation”
Published: December 2022
Examines optimal dosing strategies for NAD+ supplementation to enhance blood NAD+ concentrations.
4. “Nicotinamide Riboside Supplementation Restores Myocardial NAD+ Levels”
Published: November 2023
Discusses how direct NAD+ supplementation can improve heart function post-myocardial infarction.
5. “Effects of NAD+ Precursor Supplementation on Glucose and Lipid Metabolism”
Published: March 2022
Analyzes the impact of NAD+ supplementation on lipid profiles and glucose metabolism in humans.
6. “NAD+ Supplementation Reduces Neuroinflammation and Cell Senescence in Alzheimer’s Disease Models”
Published: September 2021
Explores the potential of direct NAD+ supplementation in mitigating neuroinflammation associated with Alzheimer’s disease.
7. “Chronic Nicotinamide Mononucleotide Supplementation Elevates NAD+ Levels in Older Adults”
Published: August 2022
Reports on the efficacy of prolonged NAD+ supplementation in increasing NAD+ concentrations among the elderly.
8. “Nicotinamide Adenine Dinucleotide Precursor Supplementation Modulates Neurite Complexity and Survival in Motor Neurons from Amyotrophic Lateral Sclerosis Models”
Published: July 2024
Investigates the effects of NAD+ precursor supplementation on motor neuron health in ALS models.
9. “Supplementation with NAD+ and Its Precursors to Prevent Cognitive Decline across Disease Contexts”
Published: August 2022
Reviews the potential of NAD+ supplementation in preventing cognitive decline across various diseases.
10. “Nicotinamide Adenine Dinucleotide (NAD) Concentration”
Published: December 2022
Discusses the effects of NMN supplementation on blood NAD concentration and related health outcomes.